Preview

Archives of Pediatrics and Pediatric Surgery

Advanced search

Features of the course of COVID-19 in children with the spread of the Omicron variant

https://doi.org/10.31146/2949-4664-apps-2-2-22-28

Abstract

The aim of the study was to assess the symptoms and identify risk factors for prolonged and complicated COVID-19 during the spread of the Omicron variant in children aged 1 month to 18 years. Materials and methods. The study included 110 children with confirmed COVID-19 of mild or moderate severity at the time of the first examination. The average age of the patients was 6.86±5.09 years. The clinical symptoms, duration of each of the identified symptoms, and complications were evaluated. Acomparative analysis of possible risk factors for prolonged course and development of pneumonia was carried out. Results. The most common cases in children with COVID-19 were an increase in body temperature (in93%), runny nose (in65%), cough (in59%), hyperemia of the posterior pharyngeal wall (in95%) and tonsils (in93%), an increase in regional lymph nodes - in 43%. Among children with the duration of COVID-19 for 10 days or more, astatistically significant late request for medical help (onaverage, by 8.26±5.46 days, compared with 3.00 ± 1.32 days with the duration of the disease up to 10 days). Pneumonia is most often registered among preschool children. The average age in the group of children diagnosed with pneumonia is significantly less than in children who did not have signs of pneumonia of this complication (4.66 ±4.78 and 7.17±4.81, respectively). Conclusions: With the spread of the Omicron variant COVID-19 in children, infection with the SARS-CoV-2 coronavirus is accompanied by symptoms of acute respiratory infection with an increase in body temperature, sore throat, hyperemia of the posterior wall of the pharynx and tonsils. Often there is an increase in regional lymph nodes, runny nose, cough, vomiting, less often - diarrhea. The prolonged course is facilitated by the late onset of adequate therapy. During the study, pneumonia was detected in 25% of children.

About the Authors

T. A. Ruzhentsova
Gabrichevsky Research Institute of Epidemiology and Microbiology; Moscow Medical University «REAVIZ»
Russian Federation


A. A. Garbuzov
Gabrichevsky Research Institute of Epidemiology and Microbiology
Russian Federation


A. V. Bitsueva
Krasnogorsk City Hospital No. 2; Reasearch Clinical Institute of Childhood of the Ministry of Health of the Moscow Region
Russian Federation


O. V. Rubleva
Instamed Medical Center (Biolab-R)
Russian Federation


S. G. Gorbunov
Reasearch Clinical Institute of Childhood of the Ministry of Health of the Moscow Region; Russian Medical Academy of Continuig Professional Education
Russian Federation


N. A. Meshkova
Sechenov Moscow Medical University
Russian Federation


R. V. Popova
Mytishchi Regional Clinical Hospital of the Ministry of Health of the Moscow Region
Russian Federation


E. N. Morozova
Krasnogorsk Hospital
Russian Federation


References

1. Bolatova D.G., Kayrgel’dinova M.K., Kazhybay M. Y. et al. Clinical characteristics of anew coronavirus infection (COVID-19) in children hospitalized in ahospital in Karaganda. Children infectious. 2022;21(1):45-48. (In Russ.) doi: 10.22627/2072-8107-2022-21-1-45-48. @@ Болатова Д. Г., Кайргельдинова М. К., Кажыбай М. Е. и др. Клиническая характеристика новой коронавирусной инфекции (COVID-19) удетей по данным детской больницы г.Караганды. Детские инфекции. 2022;21(1):45-48. doi: 10.22627/2072-8107-2022-21-1-45-48.

2. Nosyreva S.Yu., Pankov A. S., Korneev A. G. New coronavirus infection (COVID-19) in children: clinical, laboratory and diagnostic aspects. Childhood infections. 2021;20(3):23-28. (In Russ.) doi: 10.22627/2072-8107-2021-20-3-23-28. @@ Носырева С. Ю., ПаньковА. С., Корнеев А. Г. Новая коронавирусная инфекция (COVID-19) удетей: клинико-лабораторные идиагностические аспекты. Детские инфекции. 2021;20(3):23-28. doi: 10.22627/2072-8107-2021-20-3-23-28.

3. Gorelov A. V., Nikolaeva S. V., Akimkin V. G. New coronavirus infection COVID-19: features of the course in children in the Russian Federation. Pediatrics named after G. N. Speransky. 2020;99(6):57-62. (In Russ.) doi: 10.24110/0031-403X-2020-99-6-57-62. @@ Горелов А. В., Николаева С. В., Акимкин В. Г. Новая коронавирусная инфекция СОVID-19: особенности течения удетей в Российской Федерации. Педиатрия им Г. Н.Сперанского. 2020;99(6):57-62. doi: 10.24110/0031-403X-2020-99-6-57-62.

4. Ivanova R. A., Skripchenko N. V., Vishnevskaya T. V. et al. COVID-19 in children in amegalopolis: clinical, epidemiological and therapeutic aspects. Practical medicine. 2020;18(6):119-127. (In Russ.) doi: 10.32000/2072-1757-2020-6-119-127. @@ Иванова Р. А., Скрипченко Н. В., Вишневская Т. В. и др. COVID-19 удетей вмегаполисе: клинико-эпидемиологические итерапевтические аспекты. Практическая медицина. 2020;18(6):119-127. doi: 10.32000/2072-1757-2020-6-119-127.

5. Uskov A. N., Lobzin Yu.V., Rychkova S. V. et al. Course of anew coronavirus infection in children: some aspects of monitoring and analysis of mortality. Journal Infectology. 2020;12(3):12-20. (In Russ.) doi: 10.22625/2072-6732-2020-12-3-12-20. @@ Усков А. Н., Лобзин Ю. В., Рычкова С. В. и др. Течение новой коронавирусной инфекции удетей: некоторые аспекты мониторинга ианализа летальности. Журнал инфектологии. 2020;3(12):12-21. doi: 10.22625/2072-6732-2020-12-3-12-20.

6. Ludvigsson J. F.Systematic review of COVID-19 in children show milder cases and abetter prognosis than adults. Acta Paediatr. 2020;109(6):1088-1095. doi: 10.1111/apa.15270.

7. Martynova G. P., Stroganova M. A., Bogvilene Ya.A. et al. Clinical and epidemiological features of the new coronavirus infection COVID-19 in children of Krasnoyarsk. Treatment and prevention. 2021;11(1):5-12. (In Russ.) @@ Мартынова Г. П., Строганова М. А., Богвилене Я. А. и др. Клинико-эпидемиологические особенности новой коронавирусной инфекции COVID-19 удетей г.Красноярска. Лечение ипрофилактика. 2021;11(1):5-12.

8. Tagarro A., Epalza С., Santos M. et al. Screening and severity of Coronavirus disease 2019 (COVID-19) in children in Madrid, Spain. JAMA pediatrics. 2020. e201346. doi: 10.1001/jamapediatrics.2020.1346.

9. Ruzhentsova T. A., Khavkina D. A., Chukhlyaev P. V. et al. Features of clinical picture of pneumonia caused by SARS-COV-2 virus in children. Medical alphabet. 2020;34:28-31. (In Russ.) doi: 10.33667/2078-5631-2020-34-28-31. @@ Руженцова Т. А., Хавкина Д. А., Чухляев П. В. и др. Особенности клинической картины пневмонии, вызванной вирусом SARS-COV-2, удетей. Медицинский алфавит. 2020;34:28-31. doi: 10.33667/2078-5631-2020-34-28-31.

10. Popova R.V., Ruzhentsova T. A., Khavkina D. A. et al. Gastrointestinal Tract Disorders in COVID-19 Infected Children. Problems of Particularly Dangerous Infections. 2020;3:154-157. (In Russ.) doi: 10.21055/0370-1069-2020-3-154-157. @@ Попова Р. В., Руженцова Т. А., Хавкина Д. А. и др. Нарушения функции желудочно-кишечного тракта при COVID-19 удетей. Проблемы особо опасных инфекций. 2020;3:154-157. doi: 10.21055/0370-1069-2020-3-154-157.

11. Belotserkovskaya Yu.G., Romanovskikh A. G., Smirnov I. P., Sinopalnikov A. I.Long COVID-19. Consilium Medicum. 2021;23(3):261-268. (In Russ.) doi: 10.26442/20751753.2021.3.200805. @@ Белоцерковская Ю. Г., Романовских А. Г., Смирнов И. П., Синопальников А. И.Долгий COVID-19. Consilium Medicum. 2021;23(3):261-268. doi: 10.26442/20751753.2021.3.200805.

12. Temporary methodological recommendations of the Ministry of Health of the Russian Federation “Prevention, diagnosis and treatment of coronavirus infection (COVID-19)”, version 16 at: 18.08.2022. Moscow. 2022. 248 p. (inRuss.)@@ Временные методические рекомендации Минздрава России «Профилактика, диагностика илечение коронавирусной инфекции (COVID-19)», версия 16 от 18.08.2022. М, 2022. 248 с.

13. Khavkina D. A., Ruzhentsova T. A., Chukhlyaev P. V. et al. Role of desintoxication and antioxidant therapy for COVID-19: theory and practice. Epidemiology and infectious diseases. Current items. 2020;10(2):62-69. (In Russ.) doi: 10.18565/epidem.2020.2.62-69. @@ Хавкина Д. А., Руженцова Т. А., Чухляев П. В. и др. Роль дезинтоксикационной иантиоксидантной терапии влечении СOVID-19: теория ипрактика. Эпидемиология иинфекционные болезни: актуальные вопросы. 2020;10(2):62-69. doi: 10.18565/epidem.2020.2.62-69.

14. Ruzhentsova T. A., Khavkina D. A., Chukhliaev P. V. et al. Effect of anticoagulant therapy on the course of COVID-19 in comorbid patients. Problems of Virology. 2021;66(1):40-46. (In Russ.) doi: 10.36233/0507-4088-14. @@ Руженцова Т. А., Хавкина Д. А., Чухляев П. В. и др. Влияние антикоагулянтной терапии на течение COVID-19 укоморбидных пациентов. Вопросы вирусологии. 2021;66(1):40-46. doi: 10.36233/0507-4088-14.

15. Temporary methodological recommendations of the Ministry of Health of the Russian Federation “Prevention, diagnosis and treatment of coronavirus infection (COVID-19)”, version 15 at: 02.22.2022. Moscow. 2022. 224 p. (in Russ.) @@ Временные методические рекомендации Минздрава России «Профилактика, диагностика илечение коронавирусной инфекции (COVID-19)», версия 15 (22.02.2022). М, 2022. 224 с.


Review

For citations:


Ruzhentsova T.A., Garbuzov A.A., Bitsueva A.V., Rubleva O.V., Gorbunov S.G., Meshkova N.A., Popova R.V., Morozova E.N. Features of the course of COVID-19 in children with the spread of the Omicron variant. Archives of Pediatrics and Pediatric Surgery. 2024;2(2):22-28. (In Russ.) https://doi.org/10.31146/2949-4664-apps-2-2-22-28

Views: 98


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2949-4664 (Print)