Микробиота кишечника и перспективы применения пробиотиков при целиакии у детей
https://doi.org/10.31146/2949-4664-apps-2-1-121-132
Аннотация
Целиакия - хроническое заболевание, с преимущественным поражением тонкой кишки и провоцируемое употреблением глютена у генетически предрасположенных индивидуумов. Ранее проведённые масштабные исследования позволяют говорить о возможной роли микробиоты кишечника в патогенезе этого заболевания. Изменения качественно-количественных характеристик микробиоты различного генеза могут привести к нарушению регуляции иммунного ответа, что, в свою очередь, может способствовать развитию непереносимости глютена. В этом контексте является актуальным анализ данных об изменении микробиоты кишечника при целиакии и возможности её коррекции пробиотиками, как одной из стратегий лечения детей, страдающих целиакией.
Об авторах
А. И. Хавкин
Государственное Бюджетное Учреждение Здравоохранения Московской области «Научно-исследовательский клинический институт детства Министерства Здравоохранения Московской области»
Россия
Россия
Е. А. Яблокова
Государственное Бюджетное Учреждение Здравоохранения Московской области «Научно-исследовательский клинический институт детства Министерства Здравоохранения Московской области»
Россия
Россия
Н. С. Шаповалова
Государственное Бюджетное Учреждение Здравоохранения Московской области «Научно-исследовательский клинический институт детства Министерства Здравоохранения Московской области»
Россия
Россия
М. И. Ерохина
Государственное Бюджетное Учреждение Здравоохранения Московской области «Научно-исследовательский клинический институт детства Министерства Здравоохранения Московской области»
Россия
Россия
Список литературы
1. Caminero A., Verdu E. F. Celiac disease: should we care about microbes? Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2): G161-G170. doi: 10.1152/ajpgi.00099.2019.
2. Tarar Z.I., Zafar M. U., Farooq U., Basar O., Tahan V., Daglilar E. The Progression of Celiac Disease, Diagnostic Modalities, and Treatment Options. J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211053702. doi: 10.1177/23247096211053702
3. Verdu E.F., Galipeau H. J., Jabri B. Novel players in coeliac disease pathogenesis: role of the gut microbiota. Nat Rev Gastroenterol Hepatol. 2015 Sep;12(9):497-506. doi: 10.1038/nrgastro.2015.90.
4. Cenit M.C., Codoñer-Franch P., Sanz Y. Gut Microbiota and Risk of Developing Celiac Disease. J Clin Gastroenterol. 2016 Nov/Dec;50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015: S148-S152. doi: 10.1097/MCG.0000000000000688.
5. Krishnareddy S. The Microbiome in Celiac Disease. Gastroenterol Clin North Am. 2019 Mar;48(1):115-126. doi: 10.1016/j.gtc.2018.09.008.
6. Chibbar R., Dieleman L. A. The Gut Microbiota in Celiac Disease and probiotics. Nutrients. 2019 Oct 5;11(10):2375. doi: 10.3390/nu11102375.
7. Wu X., Qian L., Liu K., Wu J., Shan Z. Gastrointestinal microbiome and gluten in celiac disease. Ann Med. 2021 Dec;53(1):1797-1805. doi: 10.1080/07853890.2021.1990392.
8. Golfetto L., de Senna F. D., Hermes J., Beserra B. T, França Fda S., Martinello F. Lower bifidobacteria counts in adult patients with celiac disease on a gluten-free diet. Arq Gastroenterol. 2014 Apr-Jun;51(2):139-43. doi: 10.1590/s0004-28032014000200013.
9. Cenit M.C., Olivares M., Codoñer-Franch P., Sanz Y.Intestinal Microbiota and Celiac Disease: Cause, Consequence or Co-Evolution? Nutrients. 2015 Aug 17;7(8):6900-23. doi: 10.3390/nu7085314.
10. Cristofori F., Indrio F., Miniello V. L., De Angelis M., Francavilla R. Probiotics in Celiac Disease. Nutrients. 2018 Nov 23;10(12):1824. doi: 10.3390/nu10121824.
11. Dargenio V.N., Castellaneta S., Panico S., Papagni M. E., Dargenio C., Schettini F., Francavilla R., Cristofori F. Probiotics and gastrointestinal diseases. Minerva Pediatr (Torino). 2022 Dec;74(6):703-723. doi: 10.23736/S2724-5276.22.07031-8.
12. Valitutti F., Leonard M. M., Kenyon V., Montuori M., Piemontese P., Francavilla R., Malamisura B., Norsa L., Calvi A., Lionetti M. E., Baldassarre M., Trovato C. M., Perrone M., Passaro T., Sansotta N., Crocco M., Morelli A., Raguseo L. C., Malerba F., Elli L., Cristofori F., Catassi C., Fasano A.; CD-GEMM Team. Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease. Am J Gastroenterol. 2023 Mar 1;118(3):574-577. doi: 10.14309/ajg.0000000000002192.
13. Aljada B., Zohni A., El-Matary W. The Gluten-Free Diet for Celiac Disease and Beyond. Nutrients. 2021 Nov 9;13(11):3993. doi: 10.3390/nu13113993.
14. Thompson T., Dennis M., Higgins L. A., Lee A. R., Sharrett M. K. Gluten-free diet survey: are Americans with coeliac disease consuming recommended amounts of fibre, iron, calcium and grain foods? J Hum Nutr Diet. 2005 Jun;18(3):163-9. doi: 10.1111/j.1365-277X.2005.00607.x.
15. Pontieri P., Mamone G., De Caro S. et al. Sorghum, a healthy and gluten-free food for celiac patients as demonstrated by genome, biochemical, and immunochemical analyses. J Agric Food Chem. 2013 Mar 13;61(10):2565-71. doi: 10.1021/jf304882k.
16. Sivamaruthi B.S., Alagarsamy K., Thangaleela S., Bharathi M., Kesika P., Chaiyasut C.Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran. Foods. 2023 Mar 18;12(6):1300. doi: 10.3390/foods12061300.
17. Kaliciak I., Drogowski K., Garczyk A., Kopeć S., Horwat P., Bogdański P., Stelmach-Mardas M., Mardas M. Influence of Gluten-Free Diet on Gut Microbiota Composition in Patients with Coeliac Disease: A Systematic Review. Nutrients. 2022 May 16;14(10):2083. doi: 10.3390/nu14102083.
18. Ali B., Khan A. R. Efficacy of Probiotics in Management of Celiac Disease. Cureus. 2022 Feb 8;14(2): e22031. doi: 10.7759/cureus.22031.
19. Pecora F., Persico F., Gismondi P., Fornaroli F., Iuliano S., de’Angelis G.L., Esposito S. Gut Microbiota in Celiac Disease: Is There Any Role for Probiotics? Front Immunol. 2020 May 15;11:957. doi: 10.3389/fimmu.2020.00957.
20. Olivares M., Benítez-Páez A., de Palma G. et al. Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study. Gut Microbes. 2018 Nov 2;9(6):551-558. doi: 10.1080/19490976.2018.1451276.
21. Olivares M., Flor-Duro A., Sanz Y. Manipulation of the gut microbiome in gluten-intolerance. Curr Opin Clin Nutr Metab Care. 2021 Nov 1;24(6):536-542. doi: 10.1097/MCO.0000000000000791.
22. De Palma G., Cinova J., Stepankova R., Tuckova L., Sanz Y. Pivotal Advance: Bifidobacteria and Gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease. J Leukoc Biol. 2010 May;87(5):765-78. doi: 10.1189/jlb.0709471.
23. Leonard M.M., Valitutti F., Karathia H., Pujolassos M., Kenyon V., Fanelli B., Troisi J., Subramanian P., Camhi S., Colucci A., Serena G., Cucchiara S., Trovato C. M., Malamisura B., Francavilla R., Elli L., Hasan N. A., Zomorrodi A. R., Colwell R., Fasano A.; CD-GEMM Team. Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29): e2020322118. doi: 10.1073/pnas.2020322118.
24. Rossi R.E., Dispinzieri G., Elvevi A., Massironi S.Interaction between Gut Microbiota and Celiac Disease: From Pathogenesis to Treatment. Cells. 2023 Mar 7;12(6):823. doi: 10.3390/cells12060823.
25. D’Arienzo R., Stefanile R., Maurano F., Mazzarella G., Ricca E., Troncone R., Auricchio S., Rossi M. Immunomodulatory effects of Lactobacillus casei administration in a mouse model of gliadin-sensitive enteropathy. Scand J Immunol. 2011 Oct;74(4):335-41. doi: 10.1111/j.1365-3083.2011.02582.x.
26. Tremblay A., Xu X., Colee J., Tompkins T. A. Efficacy of a Multi-Strain Probiotic Formulation in Pediatric Populations: A Comprehensive Review of Clinical Studies. Nutrients. 2021 Jun 1;13(6):1908. doi: 10.3390/nu13061908.
27. Drabińska N., Krupa-Kozak U., Jarocka-Cyrta E.Intestinal Permeability in Children with Celiac Disease after the Administration of Oligofructose-Enriched Inulin into a Gluten-Free Diet-Results of a Randomized, Placebo-Controlled, Pilot Trial. Nutrients. 2020 Jun 10;12(6):1736. doi: 10.3390/nu12061736.
28. Demiroren K. Can a Synbiotic Supplementation Contribute to Decreasing Anti-Tissue Transglutaminase Levels in Children with Potential Celiac Disease? Pediatr Gastroenterol Hepatol Nutr. 2020 Jul;23(4):397-404. doi: 10.5223/pghn.2020.23.4.397.
29. Klemenak M., Dolinšek J., Langerholc T., Di Gioia D., Mičetić-Turk D. Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease. Dig Dis Sci. 2015 Nov;60(11):3386-92. doi: 10.1007/s10620-015-3769-7.
30. Smecuol E., Hwang H. J., Sugai E., Corso L. et al. Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease. J Clin Gastroenterol. 2013 Feb;47(2):139-47. doi: 10.1097/MCG.0b013e31827759ac.
31. Fallani M., Young D., Scott J., Norin E., Amarri S., Adam R., Aguilera M., Khanna S., Gil A., Edwards C. A., Doré J.; Other Members of the INFABIO Team.Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics. J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):77-84. doi: 10.1097/MPG.0b013e3181d1b11e.
32. Al-Toma A., Volta U., Auricchio R., Castillejo G., Sanders D. S., Cellier C., Mulder C. J., Lundin K. E.A. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019 Jun;7(5):583-613. doi: 10.1177/2050640619844125.
33. Francavilla R., Cristofori F., Vacca M., Barone M., De Angelis M. Advances in understanding the potential therapeutic applications of gut microbiota and probiotic mediated therapies in celiac disease. Expert Rev Gastroenterol Hepatol. 2020 May;14(5):323-333. doi: 10.1080/17474124.2020.1745630.
34. Seiler C.L., Kiflen M., Stefanolo J. P., Bai J. C., Bercik P., Kelly C. P., Verdu E. F., Moayyedi P., Pinto-Sanchez M. I. Probiotics for Celiac Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Am J Gastroenterol. 2020 Oct;115(10):1584-1595. doi: 10.14309/ajg.0000000000000749. Erratum in: Am J Gastroenterol. 2021 Sep 1;116(9):1968.
35. Mozafarybazargany M., Khonsari M., Sokoty L., Ejtahed H. S., Qorbani M. The effects of probiotics on gastrointestinal symptoms and microbiota in patients with celiac disease: a systematic review and meta-analysis on clinical trials. Clin Exp Med. 2023 Oct;23(6):2773-2788. doi: 10.1007/s10238-022-00987-x.
36. Johnson T.C., Diamond B., Memeo L., Negulescu H. et al. Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohorts. Clin Gastroenterol Hepatol. 2004 Oct;2(10):888-94. doi: 10.1016/s1542-3565(04)00390-8.
37. Pultz I.S., Hill M., Vitanza J. M., Wolf C., Saaby L., Liu T., Winkle P., Leffler D. A. Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease. Gastroenterology. 2021 Jul;161(1):81-93.e3. doi: 10.1053/j.gastro.2021.03.019.
38. Raju S.A., Sanders D. S., Penny H. A. Coeliac Disease and Probiotics: Clinicians Need to Provide the Evidence Base for this Unmet Need. J Gastrointestin Liver Dis. 2021 Dec 21;30(4):423-426. doi: 10.15403/jgld-4092.
39. Conte M., Nigro F., Porpora M., Bellomo C., Furone F., Budelli A. L., Nigro R., Barone M. V., Nanayakkara M. Gliadin Peptide P31-43 Induces mTOR/NFkβ Activation and Reduces Autophagy: The Role of Lactobacillus paracasei CBA L74 Postbiotc.Int J Mol Sci. 2022 Mar 26;23(7):3655. doi: 10.3390/ijms23073655.
40. Freire R., Ingano L., Serena G., Cetinbas M., Anselmo A., Sapone A., Sadreyev R. I., Fasano A., Senger S. Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease. Sci Rep. 2019 May 7;9(1):7029. doi: 10.1038/s41598-019-43426-w.
41. Bibbò S., Abbondio M., Sau R., Tanca A., Pira G., Errigo A., Manetti R., Pes G. M., Dore M. P., Uzzau S. Fecal Microbiota Signatures in Celiac Disease Patients With Poly-Autoimmunity. Front Cell Infect Microbiol. 2020 Jul 23;10:349. doi: 10.3389/fcimb.2020.00349.
42. van Beurden Y. H., van Gils T., van Gils N. A., Kassam Z., Mulder C. J., Aparicio-Pagés N. Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer. J Gastrointestin Liver Dis. 2016 Sep;25(3):385-8. doi: 10.15403/jgld.2014.1121.253.cel.
43. Collado M.C., Donat E., Ribes-Koninckx C., Calabuig M., Sanz Y. Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease. J Clin Pathol. 2009 Mar;62(3):264-9. doi: 10.1136/jcp.2008.061366.
44. Collado M.C., Donat E., Ribes-Koninckx C., Calabuig M., Sanz Y. Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease. BMC Microbiol. 2008 Dec 22;8:232. doi: 10.1186/1471-2180-8-232.
45. Vrieze A., Van Nood E., Holleman F., Salojärvi J. et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012 Oct;143(4):913-6.e7. doi: 10.1053/j.gastro.2012.06.031.
46. Ridaura V.K., Faith J. J., Rey F. E. et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013 Sep 6;341(6150):1241214. doi: 10.1126/science.1241214.
47. Garrett W.S., Lord G. M., Punit S., Lugo-Villarino G., Mazmanian S. K., Ito S., Glickman J. N., Glimcher L. H.Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007 Oct 5;131(1):33-45. doi: 10.1016/j.cell.2007.08.017.
48. Kelly C.R., Kahn S., Kashyap P., Laine L., Rubin D., Atreja A., Moore T., Wu G. Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology. 2015 Jul;149(1):223-37. doi: 10.1053/j.gastro.2015.05.008.
Рецензия
Для цитирования:
Хавкин А.И., Яблокова Е.А., Шаповалова Н.С., Ерохина М.И. Микробиота кишечника и перспективы применения пробиотиков при целиакии у детей. Архив педиатрии и детской хирургии. 2024;2(1):121-132. https://doi.org/10.31146/2949-4664-apps-2-1-121-132
For citation:
Khavkin A.I., Yablokova E.A., Shapovalova N.S., Erokhina M.I. Gut microbiota and prospects for probiotics in paediatric celiac disease. Archives of Pediatrics and Pediatric Surgery. 2024;2(1):121-132. (In Russ.) https://doi.org/10.31146/2949-4664-apps-2-1-121-132
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