Differential diagnosis of cytolysis syndrome in a 4-year-old child

Abstract

Introduction. Cytolysis syndrome is a nonspecific reaction of hepatocytes to the action of damaging factors, which is based on a violation of the permeability of the membranes of liver cells and their organelles, which leads to the release of intracellular enzymes into the blood plasma. At the same time, damaging factors can be both infectious and non-infectious, which requires a differentiated approach when verifying the clinical diagnosis. Description of the case. The article considers a clinical case of a long-term observed cytolysis syndrome in a 4-year-old child, as well as a complex and lengthy step-by-step way of differential diagnosis of this condition, which eventually allowed to establish the correct diagnosis and determine the tactics of management of this patient. To do this, the patient not only underwent blood tests for markers of hepatitis C virus, aminotransferase and creatine phosphokinase, but also genetic studies in dynamics. Conclusion. The authors draw attention to the fact that not every increase in the activity of aminotransferases is a manifestation of viral hepatitis. anamnesis should be carefully collected and an in-depth laboratory examination should be carried out to verify the cause of the developed cytolysis syndrome.