Preview

Архив педиатрии и детской хирургии

Расширенный поиск

Распространенность генетических маркеров целиакии в различных популяциях

https://doi.org/10.31146/2949-4664-apps-2-3-27-39

Аннотация

Несмотря на то, что целиакия описано давно, роль генетических факторов и механизмов предрасположенности и/или резистентности к целиакии до настоящего времени окончательного не определена. Такие факторы, как наличие HLA (гетеродимеры DQ2 и DQ8) и глютена в качестве триггера необходимы, но не достаточны для реализации целиакии. Это утверждение подтверждают работы, показывающие, что целиакия диагностировалась у пациентов без присутствия каких-либо признанных факторов риска. Долгое время считалось, что целиакия редко встречается в Азии, но несколько исследований, опубликованных в течение двух последних десятилетий, показали, что Ц выявляется и столь же широко распространена на Индийском субконтиненте и Ближнем Востоке, как и в западных странах. Среди стран Дальнего Востока сообщения о Ц особенно редки как в Корее, так и в Японии, однако выявляемость случаев заболевания в этих странах неуклонно растет. Крайне интересен анализ распространенности HLA-гаплотипов в популяции японцев, как примера, «неклассической» популяции, в которой частоты могут не соответствовать, тем частотам, которые описаны для Западной Европы. Таким образом, увеличение количества полногеномных исследований, размеров выборки позволяет не только нанести на генетическую карту целиакии новые регионы предрасположенности, но и новые генетические варианты уже известных генов, а также новые гены, что в свою очередь позволяет выявлять, детализировать уже известные механизмы развития и прогрессирования заболевания на пути к его терапии.

Об авторах

Г. Н. Янкина
Сибирский государственный медицинский университет
Россия


Е. И. Кондратьева
Научно-исследовательский клинический институт детства Министерства здравоохранения Московской области; ФГБНУ «Медико-генетический научный центр имени академика Н.П. Бочкова»
Россия


Е. В. Лошкова
Научно-исследовательский клинический институт детства Министерства здравоохранения Московской области; ФГБНУ «Медико-генетический научный центр имени академика Н.П. Бочкова»
Россия


Список литературы

1. Lebwohl B., Sanders D.S., Green P.H.R. Coeliac disease. Lancet. 2018 Jan 6;391(10115):70-81. doi: 10.1016/S0140-6736(17)31796-8.

2. Abduzhabarova Z.M. [Genetic features of the distribution of HLA class II gene variants depending on the clinical phenotypes of celiac disease].International science project. 2019;(22):16-19. (in Russ.)@@ Абдужабарова З.М. Генетические особенности распределения вариантов генов HLA II класса в зависимости от клинических фенотипов целиакии. “International science project». - 2019. - № 22. - С. 16-19.

3. Catassi C., Verdu E.F., Bai J.C., Lionetti E. Coeliac disease. Lancet. 2022;399:2413-2426. doi: 10.1016/S0140-6736(22)00794-2.

4. Lindfors K., Ciacci C., Kurppa K. et al. Coeliac disease. Nat Rev Dis Primers. 2019 Jan 10;5(1):3. doi: 10.1038/s41572-018-0054-z.

5. Virta L.J., Kaukinen K., Collin P. Incidence and prevalence of diagnosed coeliac disease in Finland: results of effective case finding in adults. Scand J Gastroenterol. 2009;44(8):933-8. doi: 10.1080/00365520903030795.

6. Lohi S., Mustalahti K., Kaukinen K. et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther. 2007 Nov 1; 26(9):1217-25. doi: 10.1111/j.1365-2036.2007.03502.x.

7. Cataldo F., Montalto G. Celiac disease in the developing countries: a new and challenging public health problem. World J Gastroenterol. 2007 Apr 21;13(15):2153-9. doi: 10.3748/wjg.v13.i15.2153.

8. Vader W., Stepniak D., Kooy Y., Mearin L., Thompson A., van Rood J.J., Spaenij L., Koning F. The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12390-5. doi: 10.1073/pnas.2135229100.

9. Voisine J., Abadie V.Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease. Front Immunol. 2021 Jun 2;12:674313. doi: 10.3389/fimmu.2021.674313.

10. Espino L., Núñez C. The HLA complex and coeliac disease.Int Rev Cell Mol Biol. 2021;358:47-83. doi: 10.1016/bs.ircmb.2020.09.009.

11. Abadie V., Kim S.M., Lejeune T. et al. IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. Nature. 2020 Feb;578(7796):600-604. doi: 10.1038/s41586-020-2003-8.

12. Tamai T., Ihara K. Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients.Int J Mol Sci. 2023 Jan 20; 24(3):2075. doi: 10.3390/ijms24032075.

13. Husby S., Koletzko S., Korponay-Szabó I. et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J. Craniofacial Surg. 2020;70:141-156. doi: 10.1097/MPG.0000000000002497.

14. Al-Toma A., Volta U., Auricchio R., Castillejo G., Sanders D.S., Cellier C., Mulder C.J., Lundin K.E.A. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United Eur. Gastroenterol. J. 2019;7:583-613. doi: 10.1177/2050640619844125.

15. Rubio-Tapia A., Hill I.D., Kelly C.P., Calderwood A.H., Murray J.A.; American College of Gastroenterology. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol. 2013 May;108(5):656-76; quiz 677. doi: 10.1038/ajg.2013.79.

16. Brown N.K., Guandalini S., Semrad C., Kupfer S.S. A Clinician’s Guide to Celiac Disease HLA Genetics. Am J Gastroenterol. 2019 Oct;114(10):1587-1592. doi: 10.14309/ajg.0000000000000310.

17. Almeida L.M., Gandolfi L., Pratesi R., Uenishi R.H., de Almeida F.C., Selleski N., Nóbrega Y.K. Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease. Autoimmune Dis. 2016;2016:5409653. doi: 10.1155/2016/5409653.

18. Ludvigsson J.F., Leffler D.A., Bai J.C. et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013 Jan;62(1):43-52. doi: 10.1136/gutjnl-2011-301346.

19. Cummins A.G., Roberts-Thomson I.C. Prevalence of celiac disease in the Asia-Pacific region. J Gastroenterol Hepatol. 2009 Aug;24(8):1347-51. doi: 10.1111/j.1440-1746.2009.05932.x.

20. Saito S., Ota S., Yamada E., Inoko H., Ota M. Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population. Tissue Antigens. 2000 Dec;56(6):522-9. doi: 10.1034/j.1399-0039.2000.560606.x.

21. Silvester J.A., Therrien A., Kelly C.P. Celiac Disease: Fallacies and Facts. Am J Gastroenterol. 2021 Jun 1;116(6):1148-1155. doi: 10.14309/ajg.0000000000001218.

22. Gujral N., Freeman H.J., Thomson A.B. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012 Nov 14;18(42):6036-59. doi: 10.3748/wjg.v18.i42.6036.

23. Yuan J., Gao J., Li X. et al. The Tip of the “Celiac Iceberg” in China: A Systematic Review and Meta-Analysis. PLoS ONE. 2013;8: e81151. doi: 10.1371/journal.pone.0081151.

24. Poddighe D., Abdukhakimova D. Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers. World J. Gastroenterol. 2021;27:2251-2256. doi: 10.3748/wjg.v27.i19.2251.

25. Singh P., Arora A., Strand T.A., Leffler D.A., Catassi C., Green P.H., Kelly C.P., Ahuja V., Makharia G.K. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin. Gastroenterol. Hepatol. 2018;16:823-836.e2. doi: 10.1016/j.cgh.2017.06.037.

26. Ashtari S., Pourhoseingholi M.A., Rostami K. et al. Prevalence of gluten-related disorders in Asia-Pacific region: A systematic review. J. Gastrointest. Liver Dis. 2019;28:95-105. doi: 10.15403/jgld.2014.1121.281.sys.

27. Comba A., Eren N.B., Demir E. Prevalence of celiac disease among school-age children in Çorum, Turkey. Turk. J. Gastroenterol. Off. J. Turk. Soc. Gastroenterol. 2018;29:595-600.

28. Choi R., Lee S.G., Lee E.H. Underutilization of diagnostic assays for celiac disease in Korea. J. Clin. Lab. Anal. 2021;35: e23913. doi: 10.1002/jcla.23913.

29. Yuan J., Zhou C., Gao J. et al. Prevalence of Celiac Disease Autoimmunity Among Adolescents and Young Adults in China. Clin. Gastroenterol. Hepatol. 2017;15:1572-1579.e1. doi: 10.1016/j.cgh.2017.04.025.

30. Zhou C., Gao F., Gao J. et al. Prevalence of coeliac disease in Northwest China: Heterogeneity across Northern Silk road ethnic populations. Aliment. Pharmacol. Ther. 2020;51:1116-1129. doi: 10.1111/apt.15737.

31. Gweon T.G., Lim C.H., Byeon S.W., Baeg M.K., Lee J.Y., Moon S.J., Kim J.S., Choi M.G. A case of celiac disease. Korean J. Gastroenterol. Taehan Sohwagi Hakhoe Chi. 2013;61:338-342. doi: 10.4166/kjg.2013.61.6.338.

32. Hwang I.K., Kim S.H., Lee U. et al. Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves’ Disease. Endocrinol. Metab. 2015;30:105-109. doi: 10.3803/EnM.2015.30.1.105.

33. Ham H., Lee B.-I., Oh H.J., Park S.H., Kim J.S., Park J.M., Cho Y.S., Choi M.-G. A case of celiac disease with neurologic manifestations misdiagnosed as amyotrophic lateral sclerosis.Intest. Res. 2017;15:540-542. doi: 10.5217/ir.2017.15.4.540.

34. Fukunaga M., Ishimura N., Fukuyama C. et al. Celiac disease in non-clinical populations of Japan. J. Gastroenterol. 2018;53:208-214. doi: 10.1007/s00535-017-1339-9.

35. Iwamoto M., Kato K., Kusumi Y., Masuda S., Nakayama T., Moriyama M. Celiac Disease Diagnosed after Gastrectomy for Gastric Cancer.Intern. Med. 2022;61:323-328. doi: 10.2169/internalmedicine.7901-21.

36. Miyagi Y. Malignant lymphoma of the small intestine associated with celiac disease. Gastrointest. Endosc. 2021;33:925-929.

37. Hayashida S., Murakami T., Tsuyama S. et al. Celiac disease: a case report detailing clinical and pathological improvement with a gluten-free diet. Nihon Shokakibyo Gakkai Zasshi. 2021;118:661-670. doi: 10.11405/nisshoshi.118.661.

38. Fujisawa M., Matsushima M., Ueda T. et al. Celiac Disease Complicated by Rhabdomyolysis.Intern. Med. 2021;60:217-222. doi: 10.2169/internalmedicine.5358-20.

39. Fukunaga M., Ishimura N., Abe T., Takeda M., Isomura M., Kinoshita Y., Ishihara S. Serological screening for celiac disease in adults in Japan: Shimane CoHRE study. JGH Open. 2020;4:558-560. doi: 10.1002/jgh3.12334.

40. Sato K., Nanri K., Ueta Y., Kanamaru K., Tanaka N., Ishiko T., Terashi H. A Case of Progressive Myoclonus Epilepsy that was Considered to be Associated with Celiac Disease. J. New Remedies Clin. 2017;66:938-944.

41. Baba Y., Matsuda A., Nishimura N. et al. A Case of Celiac Disease in Which the Clinical Symptoms and Image Findings Improved with a Gluten Free Diet. Stomach Intest. 2015;50:950-956.

42. Nakazawa H., Makishima H., Ito T. et al. Screening Tests Using Serum Tissue Transglutaminase IgA May Facilitate the Identification of Undiagnosed Celiac Disease among Japanese Population.Int. J. Med. Sci. 2014;11:819-823. doi: 10.7150/ijms.8854.

43. Kishi M., Yao K., Hirai F. et al. Celiac Disease in Whom Magnifying Endscopy was Useful for Diagnosis It, Report of a Case. Stomach Intest. 2014;49:395-404.

44. Makishima H., Komiyama Y., Asano N., Momose K., Nakamura S., Ishida F. Peripheral T-cell Lymphoma Following Diffuse Large B-cell Lymphoma Associated with Celiac Disease.Intern. Med. 2008;47:295-298. doi: 10.2169/internalmedicine.47.0500.

45. Yasuoka H., Masuo T., Hashimoto K. et al. Enteropathy-type T-cell Lymphoma that was Pathologically Diagnosed as Celiac Disease.Intern. Med. 2007;46:1219-1224. doi: 10.2169/internalmedicine.46.6377.

46. Makishima H., Ito T., Kodama R., Asano N., Nakazawa H., Hirabayashi K., Nakamura S., Ota M., Akamatsu T., Kiyosawa K., et al.Intestinal Diffuse Large B-Cell Lymphoma Associated with Celiac Disease: A Japanese Case.Int. J. Hematol. 2006;83:63-65. doi: 10.1532/IJH97.05131.

47. Karell K., Louka A.S., Moodie S.J., Ascher H., Clot F., Greco L., Ciclitira P.J., Sollid L.M., Partanen J. Hla types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: Results from the european genetics cluster on celiac disease. Hum. Immunol. 2003;64:469-477. doi: 10.1016/S0198-8859(03)00027-2.

48. Megiorni F., Mora B., Bonamico M., Barbato M., Nenna R., Maiella G., Lulli P., Mazzilli M.C. HLA-DQ and risk gradient for celiac disease. Hum. Immunol. 2009;70:55-59. doi: 10.1016/j.humimm.2008.10.018.

49. Pietzak M.M., Schofield T.C., McGinniss M.J., Nakamura R.M. Stratifying Risk for Celiac Disease in a Large At-Risk United States Population by Using HLA Alleles. Clin. Gastroenterol. Hepatol. 2009;7:966-971. doi: 10.1016/j.cgh.2009.05.028.

50. Almeida L.M., Gandolfi L., Pratesi R., Uenishi R.H., de Almeida F.C., Selleski N., Nóbrega Y.K.D.M. Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease. Autoimmune Dis. 2016;2016:5409653. doi: 10.1155/2016/5409653.

51. Megiorni F., Mora B., Bonamico M., Barbato M., Nenna R., Maiella G., Lulli P., Mazzilli M.C. HLA-DQ and risk gradient for celiac disease. Hum. Immunol. 2009;70:55-59. doi: 10.1016/j.humimm.2008.10.018.

52. Murad H., Jazairi B., Khansaa I., Olabi D., Khouri L. HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation. BMC Gastroenterol. 2018;18:70. doi: 10.1186/s12876-018-0802-2.

53. Tinto N., Cola A., Piscopo C., Capuano M., Galatola M., Greco L., Sacchetti L. High Frequency of Haplotype HLA-DQ7 in Celiac Disease Patients from South Italy: Retrospective Evaluation of 5,535 Subjects at Risk of Celiac Disease. PLoS ONE. 2015;10: e0138324. doi: 10.1371/journal.pone.0138324.

54. Wang H., Zhou G., Luo L. et al. Serological Screening for Celiac Disease in Adult Chinese Patients With Diarrhea Predominant Irritable Bowel Syndrome. Medicine. 2015;94: e1779. doi: 10.1097/MD.0000000000001779.

55. Gweon T.G., Lim C.H., Byeon S.W., Baeg M.K., Lee J.Y., Moon S.J., Kim J.S., Choi M.G. A case of celiac disease. Korean J. Gastroenterol. Taehan Sohwagi Hakhoe Chi. 2013;61:338-342. doi: 10.4166/kjg.2013.61.6.338.

56. Hwang I.K., Kim S.H., Lee U., Chin S.O., Rhee S.Y., Oh S., Woo J.-T., Kim S.-W., Kim Y.S., Chon S. Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves’ Disease. Endocrinol. Metab. 2015;30:105-109. doi: 10.3803/EnM.2015.30.1.105.

57. Ham H., Lee B.-I., Oh H.J., Park S.H., Kim J.S., Park J.M., Cho Y.S., Choi M.-G. A case of celiac disease with neurologic manifestations misdiagnosed as amyotrophic lateral sclerosis.Intest. Res. 2017;15:540-542. doi: 10.5217/ir.2017.15.4.540.

58. SHaripova M.N. [Clinical, epidemiological and genetic features of celiac disease in children of Kazakhstan]. Pediatria n. a. G.N. Speransky. 2009; 88 (1):106-108. (in Russ.)@@ Шарипова М.Н. Клинико-эпидемиологические и генетические особенности целиакии у детей Казахстана. Педиатрия им. Г.Н. Сперанского. 2009. -Том 87, № 1. -C. 106-108.

59. Abdujabarova Z.M., Kamilova A.T. The importance of genetic factors in the development of celiac disease in children of the Uzbek population. Modern Pediatrics. Ukraine. 2020;7(111): 22-27. doi: 10.15574/SP.2020.111.22.

60. Dmitrieva Y.A., Roslavtseva E.A., Kuryaninova V.A. et al. Structure of the HLA-DR-DQ-genotype in children with coeliac disease. Meditsinskiy sovet = Medical Council. 2020;(10):74-80. (In Russ.) doi: 10.21518/2079-701X-2020-10-74-80.@@ Дмитриева Ю.А., Рославцева Е.А., Курьянинова В.А. и др. Структура HLA-DR-DQ-генотипа у детей с целиакией. Медицинский Совет. 2020;(10):74-80. doi: 10.21518/2079-701X-2020-10-74-80.

61. Kondratieva E.I., Yankina G.N. HLA markers of celiac disease and their impact on the course of the disease. Issues of pediatric dietetics. 2011;9(2)73-74. (in Russ.)@@ Кондратьева Е.И., Янкина Г.Н. HLA-маркеры целиакии и их влияние на течение заболевания. Вопросы детской диетологии. - 2011. - Т. 9, № 2. - С. 73-74.

62. Sharma A., Liu X., Hadley D., Hagopian W., Liu E., Chen W.M., Onengut-Gumuscu S., Simell V., Rewers M., Ziegler A.G., Lernmark Å., Simell O., Toppari J., Krischer J.P., Akolkar B., Rich S.S., Agardh D., She J.X.; TEDDY Study Group. Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort. PLoS One. 2016 Mar 25;11(3): e0152476. doi: 10.1371/journal.pone.0152476.

63. Dotsenko V., Oittinen M., Taavela J. et al. Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge. Cell Mol Gastroenterol Hepatol. 2021;11(1):13-32. doi: 10.1016/j.jcmgh.2020.07.010.

64. Rondanelli M., Faliva M.A., Gasparri C. et al. Micronutrients dietary supplementation advices for celiac patients on long-term gluten-free diet with good compliance: a review. Medicina (Kaunas). 2019;55:337.

65. Syage J.A., Kelly C.P., Dickason M.A. et al. Determination of gluten consumption in celiac disease patients on a gluten-free diet. Am J Clin Nutr. 2018;107:201-207.

66. Kreutz J.M., Adriaanse M.P.M., van der Ploeg E.M.C., Vreugdenhil A.C.E. Narrative review: nutrient deficiencies in adults and children with treated and untreated celiac disease. Nutrients. 2020;12:500.

67. van der Graaf A., Zorro M.M., Claringbould A., Võsa U., Aguirre-Gamboa R., Li C., Mooiweer J., Ricaño-Ponce I., Borek Z., Koning F., Kooy-Winkelaar Y., Sollid L.M., Qiao S.W., Kumar V., Li Y., Franke L., Withoff S., Wijmenga C., Sanna S., Jonkers I.; BIOS Consortium. Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease. Front Genet. 2021 Jan 25;11:562434. doi: 10.3389/fgene.2020.562434.

68. Ricaño-Ponce I., Gutierrez-Achury J., Costa A.F., Deelen P., Kurilshikov A., Zorro M.M., Platteel M., van der Graaf A.; Consortium for the study of genetic associations of celiac disease in Latin-America; Sanna S., Daffra O., Zhernakova A., Fu J., Trynka G., Smecuol E., Niveloni S.I., Bai J.C., Kumar V., Wijmenga C. Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease. Eur J Hum Genet. 2020 Mar;28(3):313-323. doi: 10.1038/s41431-019-0520-4.

69. Carreras J. Artificial Intelligence Analysis of Celiac Disease Using an Autoimmune Discovery Transcriptomic Panel Highlighted Pathogenic Genes including BTLA. Healthcare (Basel). 2022 Aug 16;10(8):1550. doi: 10.3390/healthcare10081550.

70. Leonard M.M., Sapone A., Catassi C., Fasano A. Celiac Disease and Nonceliac Gluten Sensitivity: A Review. JAMA. 2017 Aug 15; 318(7):647-656. doi: 10.1001/jama.2017.9730.

71. Uhde M., Yu X., Bunin A., Brauner C. et al. Phenotypic shift of small intestinal intra-epithelial type 1 innate lymphoid cells in celiac disease is associated with enhanced cytotoxic potential. Clin. Exp. Immunol. 2020;200:163-175. doi: 10.1111/cei.13414.

72. Mazzarella G. Effector and suppressor T cells in celiac disease. World J. Gastroenterol. 2015;21:7349-7356. doi: 10.3748/wjg.v21.i24.7349.

73. Schumann M., Siegmund B., Schulzke J.D., Fromm M. Celiac Disease: Role of the Epithelial Barrier. Cell. Mol. Gastroenterol. Hepatol. 2017;3:150-162. doi: 10.1016/j.jcmgh.2016.12.006.

74. Høydahl L.S., Richter L., Frick R. et al. Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients with Celiac Disease. Gastroenterology. 2019;156:1428-1439.e10. doi: 10.1053/j.gastro.2018.12.013.

75. Pohjanen V.M., Kokkonen T.S., Arvonen M. et al. Decreased Expression of Protease Inhibitor 9, a Granzyme B Inhibitor, in Celiac Disease: A Potential Mechanism in Enterocyte Destruction and Villous Atrophy.Int. J. Immunopathol. Pharmacol. 2013;26:897-905. doi: 10.1177/039463201302600408.

76. Bauché D., Joyce-Shaikh B., Jain R. et al. LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis. Immunity. 2018;49:342-352.e5. doi: 10.1016/j.immuni.2018.07.007.

77. van Leeuwen M.A., Costes L.M.M., van Berkel L.A. et al. Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-γ-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance. Mucosal Immunol. 2017;10:635-649. doi: 10.1038/mi.2016.76.

78. Villarino A.V., Sciumè G., Davis F.P., Iwata S., Zitti B., Robinson G.W., Hennighausen L., Kanno Y., O’Shea J.J. Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells. J. Exp. Med. 2017;214:2999-3014. doi: 10.1084/jem.20150907.

79. Gilbert S., Zhang R., Denson L., Moriggl R., Steinbrecher K., Shroyer N., Lin J., Han X. Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation. EMBO Mol. Med. 2012;4:109-124. doi: 10.1002/emmm.201100192.

80. Schuppan D., Dieterich W. Epidemiology, Pathogenesis, and Clinical Manifestations of Celiac Disease in Adults. [(accessed on 13 July 2022)]. Available online: https://www.uptodate.com/contents/epidemiology-pathogenesis-and-clinical-manifestations-of-celiac-disease-in-adults?source=history_widget [Ref list]

81. Rubin C.E., Brandborg L.L., Phelps P.C., Taylor H.C., Jr. Studies of celiac disease I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue. Gastroenterology. 1960;38:28-49. doi: 10.1016/S0016-5085(60)80115-1.

82. Sharma N., Bhatia S., Chunduri V., Kaur S., Sharma S., Kapoor P., Kumari A., Garg M. Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them. Front. Nutr. 2020;7:6. doi: 10.3389/fnut.2020.00006.

83. Hujoel I.A., Murray J.A. Refractory Celiac Disease. Curr. Gastroenterol. Rep. 2020;22:18. doi: 10.1007/s11894-020-0756-8.

84. Belmer S.V., Revnova M.O. [Celiac disease in children and adults]. Moscow, GEOTAR, 2024. 293 p. (in Russ.)@@ Целиакия у детей и взрослых/ Под редакцией Бельмера С.В., Ревновой М.О. Москва, ГЭОТАР, 2024.-293 с.


Рецензия

Для цитирования:


Янкина Г.Н., Кондратьева Е.И., Лошкова Е.В. Распространенность генетических маркеров целиакии в различных популяциях. Архив педиатрии и детской хирургии. 2024;2(3):27-39. https://doi.org/10.31146/2949-4664-apps-2-3-27-39

For citation:


Yankina G.N., Kondratieva E.I., Loshkova E.V. Prevalence of genetic markers of celiac disease in different populations. Archives of Pediatrics and Pediatric Surgery. 2024;2(3):27-39. (In Russ.) https://doi.org/10.31146/2949-4664-apps-2-3-27-39

Просмотров: 116


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2949-4664 (Print)