Multifactorial diseases in the genesis of perinatal pathology
https://doi.org/10.31146/2949-4664-apps-2-3-4-9
Abstract
A team of authors have conducted a study on the influence of multifactorial diseases of relatives of three generations of two lines of descent on the formation of perinatal pathology in children. To conduct the study, a special questionnaire was developed, consisting of 8 blocks, one of which allows to identify family perinatal problems. The analysis of the data obtained showed that an unfavorable perinatal period of parents increases the risk of having a child with perinatal pathology, and a family history of preterm birth increases the frequency of the birth of a premature child. The study revealed that the highest impact on the development of multifactorial diseases in adulthood is exerted by child health disorders in the perinatal period, such as prematurity, intrauterine hypoxia/asphyxia during childbirth, respiratory disorders and birth trauma. In turn, a multifactorial pathology in relatives, among which the most common are hypertension (18.7%), coronary heart disease (17.3%) and gastric ulcer (10.5%) with the burden increasing from generation to generation, serves as a risk factor for the birth of a child with perinatal pathology.
About the Authors
T. A. Sokolovskaya
Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russia
Russian Federation
Russian Federation
N. D. Odinaeva
Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region
Russian Federation
Russian Federation
V. S. Stupak
Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russia
Russian Federation
Russian Federation
References
1. Yurov I. Yu., Vorsanova S.G., Voinova V. Yu., Churnosov M.I., Yurov Yu.B. Cytogenetic, molecular and clinical basis of genetically determined diseases. Moscow: Publishing House of the Academy of Natural Sciences, 2019. 164 p. (in Russ.) ISBN: 978-5-91327-581-3. doi: 10.17513/np.351.@@ Цитогенетические, молекулярные и клинические основы генетически обусловленных болезней: учебное пособие / И.Ю. Юров, С.Г. Ворсанова, В.Ю. Воинова, М.И. Чурносов, Ю.Б. Юров. - М.: Издательский дом Академии Естествознания, 2019. - 164 с. ISBN: 978-5-91327-581-3. doi: 10.17513/np.351.
2. Shi C., de Wit S., Učambarlić E., Markousis-Mavrogenis G. et al. Multifactorial Diseases of the Heart, Kidneys, Lungs, and Liver and Incident Cancer: Epidemiology and Shared Mechanisms. Cancers (Basel). 2023 Jan 25;15(3):729. doi: 10.3390/cancers15030729.
3. Shmatova Yu.E., Razvarina I.N., Gordievskaya A.N. Parent-related risk factors affecting child health (on the results of a cohort monitoring study for 25 years). Economic and Social Changes: Facts, Trends, Forecast. 2023;16(2), 166-189. (in Russ.) doi: 10.15838/esc.2023.2.86.9.@@ Шматова Ю.Е., Разварина И.Н., Гордиевская А.Н. Факторы риска здоровью ребенка со стороны родителей (по результатам когортного мониторинга за 25 лет). Экономические и социальные перемены: факты, тенденции, прогноз. 2023; 16(2): 166-189. doi: 10.15838/esc.2023.2.86.9.
4. Razvarina I.N., Shmatova Yu.E. Prevalence of risk factors for child health on the father’s side. Monitoring results. Human health, theory and methodology of physical culture and sports. 2022; 27 (3): 65-75. (in Russ.) doi: 10.14258/zosh(2022)3.05.@@ Разварина И.Н., Шматова Ю.Е. Распространенность факторов риска здоровью ребенка со стороны отца. Результаты мониторинга. Здоровье человека, теория и методика физической культуры и спорта. 2022; 27 (3): 65-75. doi: 10.14258/zosh(2022)3.05.
5. Ornoy A., Becker M., Weinstein-Fudim L., Ergaz Z. Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review.Int J Mol Sci. 2021 Mar 15;22(6):2965. doi: 10.3390/ijms22062965.
6. Antonova K.V., Tanashyan M.M., Raskurazhev A.A. et al. Obesity and the nervous system. Obesity and metabolism. 2024; 21 (1): 68-78. (in Russ.) doi: 10.14341/omet13019.@@ Антонова К.В., Танашян М.М., Раскуражев А.А. и соавт. Ожирение и нервная система. Ожирение и метаболизм. 2024; 21 (1): 68-78. doi: 10.14341/omet13019.
7. Flores-Dorantes M.T., Díaz-López Y.E., Gutiérrez-Aguilar R. Environment and Gene Association with Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases. Front Neurosci. 2020 Aug 28; 14: 863. doi: 10.3389/fnins.2020.00863.
8. Kankowski L., Ardissino M., McCracken C., Lewandowski A.J. et al. The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review. Front Endocrinol (Lausanne). 2022 May 20; 13: 868441. doi: 10.3389/fendo.2022.868441.
9. Corbett M.A., Depienne C., Veneziano L., Klein KM. et al. Genetics of familial adult myoclonus epilepsy: From linkage studies to noncoding repeat expansions. Epilepsia. 2023 Jun;64 Suppl 1(Suppl 1): S14-S21. doi: 10.1111/epi.17610. Epub 2023 Apr 17.
10. Rozensztrauch A., Kołtuniuk A. The Quality of Life of Children with Epilepsy and the Impact of the Disease on the Family Functioning.Int J Environ Res Public Health. 2022 Feb 17; 19(4):2277. doi: 10.3390/ijerph19042277.
11. Deolmi M., Decarolis N.M., Motta M., Makrinioti H. et al. Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors.Int J Environ Res Public Health. 2023 Jan 27;20(3):2294. doi: 10.3390/ijerph20032294.
12. Khuraseva A.B., Kuznetsova I.V. The relationship of birth weight with the risk of cardiovascular pathology and the possibility of cardiovascular prevention. Medical alphabet. 2019; 4 (33-408): 15-30. (in Russ.) doi: 10.33667/2078-5631-2019-4-33(408)-25-30.@@ Хурасева А.Б., Кузнецова И.В. Взаимосвязь массы тела при рождении с риском сердечно-сосудистой патологии и возможности кардиоваскулярной профилактики. Медицинский алфавит. 2019; 4 (33-408): 15-30. doi: 10.33667/2078-5631-2019-4-33(408)-25-30.
13. Ubags N.D.J., Alejandre Alcazar M.A., Kallapur S.G., Knapp S. et al. Early origins of lung disease: towards an interdisciplinary approach. Eur Respir Rev. 2020 Oct 1;29(157):200191. doi: 10.1183/16000617.0191-2020.
14. Sehgal A., Alexander B.T., Morrison J.L., South A.M. Fetal Growth Restriction and Hypertension in the Offspring: Mechanistic Links and Therapeutic Directions. J Pediatr. 2020 Sep; 224:115-123.e2. doi: 10.1016/j.jpeds.2020.05.028. Epub 2020 May 22.
15. Wang B., Zeng H., Liu J., Sun M. Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases. Front Neurosci. 2021 Oct 25; 15: 755554. doi: 10.3389/fnins.2021.755554.
16. Shestak A.G., Rumyantseva V.A., Kurlenkova A.S. Kinship and pedigrees in genetics and anthropology. Horizons of humanitarian knowledge. (in Russ.) 2021; (2): 18-36. doi: 10.17805/ggz.2021.2.2.@@ Шестак А.Г., Румянцева В.А., Курленкова А.С. Родство и родословные в генетике и антропологии. Горизонты гуманитарного знания. 2021; (2): 18-36. doi: 10.17805/ggz.2021.2.2.
17. Shor T., Kalka I., Geiger D., Erlich Y. et al. Estimating variance components in population scale family trees. PLoS Genet. 2019 May 9;15(5): e1008124. doi: 10.1371/journal.pgen.1008124.
18. Diaz-Santana M.V., O’Brien K.M., D’Aloisio A.A., Regalado G. et al. Perinatal and postnatal exposures and risk of young-onset breast cancer. Breast Cancer Res. 2020 Aug 13;22(1):88. doi: 10.1186/s13058-020-01317-3.
19. Shevtsova O.G., Moiseeva K.E., Berezkina E.N., Kharbediya Sh.D. Some results of assessing the incidence of gestational diabetes mellitus. Medicine and healthcare organization. 2019; 4(1): 29-34. (in Russ.)@@ Шевцова О.Г., Моисеева К.Е., Березкина Е.Н., Харбедия Ш.Д. Некоторые результаты оценки заболеваемости гестационным сахарным диабетом. Медицина и организация здравоохранения. 2019; 4(1): 29-34.
20. Juber N.F., Abdulle A., AlJunaibi A., AlNaeemi A. et al. Maternal Early-Life Risk Factors and Later Gestational Diabetes Mellitus: A Cross-Sectional Analysis of the UAE Healthy Future Study (UAEHFS).Int J Environ Res Public Health. 2022 Aug 19; 19(16):10339. doi: 10.3390/ijerph191610339.
21. Walle K.M., Askeland R.B., Gustavson K., Mjaaland S. et al. Risk of attention-deficit hyperactivity disorder in offspring of mothers with infections during pregnancy. JCPP Adv. 2022 Mar 10;2(2): e12070. doi: 10.1002/jcv2.12070.
22. Boytsova E.V., Titova O.N., Ovsyannikov D. Yu., Bogdanova A.V. Respiratory consequences of bronchopulmonary dysplasia in children, adolescents and adults. Pulmonology. 2017; 27(1): 87-96. (in Russ.) doi: 10.18093/0869-0189-2017-27-1-87-97.@@ Бойцова Е.В., Титова О.Н., Овсянников Д.Ю., Богданова А.В. Респираторные последствия бронхолегочной дисплазии у детей, подростков и взрослых. Пульмонология. 2017; 27(1): 87-96. doi: 10.18093/0869-0189-2017-27-1-87-97.
23. Pichugina S.V., Evseeva G.P., Suprun S.V. et al. Outcomes of bronchopulmonary dysplasia in children. Amur Medical Journal. 2018; 4 (24): 14-17. (in Russ.) doi: 10.1056/NEJMra067279.@@ Пичугина С.В., Евсеева Г.П., Супрун С.В. и соавт. Исходы бронхолегочной дисплазии у детей. Амурский медицинский журнал. 2018; 4 (24): 14-17. doi: 10.1056/NEJMra067279.
24. Shen G., Hu S., Zhao Z., Zhang L. et al. Antenatal Hypoxia Accelerates the Onset of Alzheimer’s Disease Pathology in 5xFAD Mouse Model. Front Aging Neurosci. 2020 Aug 21; 12: 251. doi: 10.3389/fnagi.2020.00251.
25. Tarkowska A. Hypoxic-Ischemic Brain Injury after Perinatal Asphyxia as a Possible Factor in the Pathology of Alzheimer’s Disease. In: Pluta R, editor. Cerebral Ischemia [Internet]. Brisbane (AU): Exon Publications; 2021 Nov 6. Chapter 4.
26. Gedzun V.R., Khukhareva D.D., Sarycheva N.Y., Kotova M.M., et al. Perinatal Stressors as a Factor in Impairments to Nervous System Development and Functions: Review of In Vivo Models. Neurosci Behav Physiol. 2023;53(1):61-69. doi: 10.1007/s11055-023-01391-y.
Review
For citations:
Sokolovskaya T.A., Odinaeva N.D., Stupak V.S. Multifactorial diseases in the genesis of perinatal pathology. Archives of Pediatrics and Pediatric Surgery. 2024;2(3):4-9. (In Russ.) https://doi.org/10.31146/2949-4664-apps-2-3-4-9
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